Computational Biology

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AlphaFold3-Guided ContactSeek Rewrites Base Editors to Cut Off-Target Edits

It offers a fast route to safer base editors by using AlphaFold3 to map and redesign protein–DNA contacts.

3D Genome Rearrangement Found in Alzheimer's Brain Cells, Study Shows

Researchers Deliver 4D Whole-Cell Simulation That Replicates Minimal Bacterium’s Full Life Cycle

Evo 2, an Open DNA Foundation Model, Debuts in Nature

Social Partners' Genes Sway Gut Microbiomes, Rat Megastudy Finds

AI Model popEVE Delivers Proteome-Wide Severity Scores for Rare-Disease Diagnosis

UW Engineers Program Proteins to Make Logic‑Gated Decisions for Targeted Drug Delivery

Scripps Team Designs Ultra-Stable Synthetic Membrane Proteins to Decode Common Folding Motif

UCLA Tool Charts Thousands of mRNA Stability Variants Linked to Autoimmune Risk

Mount Sinai Team Publishes MARQO, AI Pipeline for Faster Whole-Slide Cancer Tissue Analysis

Yale’s ChronODE Pinpoints Gene Activation Windows in the Developing Brain

AI-Informed Pipeline Accelerates Bi-Specific CAR-T Design and Clears Tumors in Mice

BigHorn Tool Reveals Coordinated Transcriptional and Post-Transcriptional Control by lncRNAs

Brain Aging Clock Uncovers 453 Rejuvenating Compounds and Validates Three in Aged Mice

Computational Study Maps When Sleep Strengthens Synaptic Connections

Artificial Enzymes Designed by Computers Rival Natural Catalysts

moPepGen Graph Algorithm Quadruples Protein Variant Detection in Tumor Samples

New AI Model Maps Gene Combinations Driving Complex Diseases

Ohio State Researchers Develop PANDA for Noninvasive Colorectal Cancer Diagnosis and Monitoring