Health ❯ Therapeutics

Drug Development

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Cancer Protein Cystatin‑C Triggers Amyloid Clearance in Alzheimer’s Mouse Models

The Cell study reports that cystatin‑C from certain tumors activated microglia via TREM2 to clear amyloid in mouse brains.

Gut Macrophages Propel Parkinson’s-Like Spread to the Brain in UCL Mouse Study

Gut Microbe Molecule TMA Inhibits IRAK4, Easing Diet-Driven Inflammation in Diabetes Models

Single Psilocybin Dose Rewires Brain-Wide Circuits in Mice, Cell Study Finds

Study Pinpoints GPR25 as Switch for Tissue-Resident Memory T Cell Formation

Study Ties Obesity to Alzheimer’s Plaque via Fat-Derived Vesicles

Study Identifies Stress-Activated Ubiquitin Precursor That Enhances Proteostasis and Longevity

Gene Therapy Shows 75% Slower Huntington’s Decline in Early Trial

Neuron-Microglia Signal Near Plaques Emerges as a Potential Alzheimer’s Target

Triple Antibody Cocktail Shows Broad Protection Against Influenza A in Mice, Resists Viral Escape

MAOB Inhibitor KDS2010 Lifts Astrocytic 'Brake' to Promote Spinal Cord Repair

Brown Fat Protein Neuritin 1 Boosts Energy Burning in Animals as New Obesity Target

Blocking Axon Degeneration Slows Glioblastoma in Mice, Nature Study Finds

Enteric Neurons Harness ADM2 to Drive Gut Repair in IBD Models

Mitochondrial Designer Receptor Validates Causal Role in Neurodegeneration and Restores Memory in Mice

Researchers Identify Lithium Deficiency as Alzheimer’s Cause and Reverse Pathology in Mice

Reactivating Liver Clock Gene Eases Cancer-Induced Wasting in Mice

PAR1 Receptor Drives Lung Lymphatic Remodeling to Accelerate Fluid Clearance

Blocking Imidazole Propionate Receptor Prevents Early Atherosclerosis in Preclinical Models

Hundreds of Non-Amyloid Proteins Tied to Age-Related Cognitive Decline