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Gene Regulation

MicroRNAs Transcription Factors MicroRNA Long Non-Coding RNAs microRNA microRNA Discovery Regulatory RNA Dosage Compensation MicroRNA Function LUC7 Proteins Cancer Biology Signaling Molecules Aldh1a2 Gene Methylation Pathways Endogenous Retroviruses Epigenetics CDK12/13 SETD2 RNA Sequencing Inflammation RNA Isoforms Chromosome 21 Long Non-Coding RNA Nonsense-Mediated mRNA Decay Zfy Gene Function Transcription Transcriptional Regulators TCF/LEF Proteins MAP-kinase Pathway Oncogenes Gene Activity

Excess HMGN1 Identified as Driver of Down Syndrome Heart Defects

Researchers trace Down syndrome heart defects to excess HMGN1 using mosaic cell models, CRISPRa screens, with rescue confirmed in mice.