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Molecular Biology

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Receptor Pathway Lets Antisense Drugs Escape Endosomes to Silence KRAS in Pancreatic Cancer

The discovery points to using CD44 or EPHA2 as delivery targets together with short, controlled inhibition of cellular repair to raise ASO potency.

Dana-Farber Reports Metabolically Activated Molecular Glue and New Discovery Platform

XJ-4-85 Forces Metabolic Collapse in Tumors

Major Review Finds Lower Protein Triggers Metabolic Changes Linked to Longer Life in Animals

Scientists Identify TRNAU1AP Pathway That Sustains Glioblastoma Stem Cells

PIKfyve Loss Breaks Photoreceptor Recycling and Raises Drug Safety Concerns

AlphaFold3-Guided ContactSeek Rewrites Base Editors to Cut Off-Target Edits

Scientists Produce First Structural In‑Cell Map of Influenza A–Host Protein Contacts

SORLA Protein Reduces Tau Damage and Preserves Brain in Mouse Models

AI Designs Synthetic CRISPR-Like Enzymes That Work in Bacteria, Plants and Human Cells

WashU Team Uses In‑Body Click Chemistry to Assemble Dual‑Target Cancer Drugs

Susumu Tonegawa, Nobel Laureate in Medicine, Dies at 86

Scientists Detect First Sugar in Interstellar Space

Chai Discovery Raises $400 Million to Scale AI Drug Design

Celtarys Launches Fluorescent Kit to Replace Radioactive Preclinical Assays

Genome-Scale CRISPRi Atlas Maps Function of Nearly 11,700 Genes in Human Stem Cells

Human‑Safe Drug Restores Neuronal DNA Repair in Mouse Model of Alzheimer’s

Space Conditions Cause Rapid, Aging‑Like Liver Changes, UCF Study Finds

Scientists Map Bacterial Blueprint That Builds a Natural HDAC Cancer Drug

Police Return to Barcelona Lab as Swine Fever Probe Reaches Madrid