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3d ago

Preclinical Studies Confirm NKAPL as Lung Cancer Tumor Suppressor, Prompt Demethylation Therapy Development

Findings that NKAPL halts tumor growth through TRIM21 stabilization with NF-κB inhibition have led researchers to advocate demethylation-based treatments

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Overview

  • NKAPL overexpression in mouse xenograft models resulted in significantly smaller tumors and reduced lung metastases.
  • Mechanistic studies show NKAPL binds to and stabilizes TRIM21, diminishing p65 phosphorylation and suppressing NF-κB-driven inflammatory signaling.
  • Restoration of NKAPL expression in NSCLC cell lines induced apoptosis, cell cycle arrest, and inhibited proliferation, migration and invasion.
  • Frequent promoter hypermethylation of NKAPL in patient tumor samples underscores its utility as a potential diagnostic biomarker.
  • Investigators propose developing demethylation-based therapies to reactivate NKAPL and disrupt NF-κB-mediated cancer progression in clinical settings.