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APOE4 Reprograms Brain Vessel Cells and Impairs Astrocyte Waste Clearance

This preclinical research identifies TGF-β and astrocyte cholesterol-lysosome pathways as drug targets to restore vessel health.

Mutant Astrocytes Drive Childhood Epilepsy in Tuberous Sclerosis

Mitochondrial Metabolism Turns On Inflammatory Genes in Aging Cells

Alcohol Remodels Decision-Making Circuit Differently in Amyloid and Tau Mouse Models

AI-Designed Miniproteins Target GPCRs in Nature Study

Colitis Leaves Lasting Epigenetic Scars That Speed Colon Tumor Growth in Mice

‘Dancing Molecules’ Therapy Regenerates Nerves in Advanced Human Spinal Cord Organoids

UCSF, UCLA Pinpoint CUL5 Complex That Clears Toxic Tau in Human Neurons

ISS Study Finds Microgravity Reshapes Phage–Bacteria Evolution, Boosting Activity Against Drug-Resistant E. coli

Lab-Grown 'Mini-Noses' Reveal Why RSV Hits Infants Harder

Study Ties Obesity to Alzheimer’s Plaque via Fat-Derived Vesicles

Kidney Organoids Tie APOL1 Risk Variants to Mitochondrial Failure in Podocytes

Alzheimer’s Study Ties Familial SORL1 Variant to Fewer, Weaker Brain Exosomes

Homocysteine Tied to Aortic Stiffening in Rabbit Study

UCLA Tool Charts Thousands of mRNA Stability Variants Linked to Autoimmune Risk

MIT-Led Cell Atlas Charts Epigenomic Breakdown in Alzheimer’s Progression

PNAS Study Identifies CHP1 as Master Regulator of Lipid Droplet Growth

JAX Mouse Study Links Retinal Vessel Changes to Dementia Risk, Launching Human Evaluation

ALS Study Identifies 39-Gene Vulnerability Signature and Cross-Species Biomarkers

Thymosin β4 Reverses Early Alzheimer’s Defects in Organoids and Mouse Models