Overview

• Depleting CHP1 in cell models led to markedly smaller lipid droplets, indicating a central role in cellular fat storage.
• CHP1 stabilizes and activates microsomal GPAT enzymes, particularly GPAT3 and GPAT4, and directs them to droplet surfaces where triacylglycerols are produced.
• Biochemical assays and an AlphaFold3‑predicted GPAT4–CHP1 complex support a direct interaction underlying the mechanism.
• The findings were published August 28, 2025, in the Proceedings of the National Academy of Sciences (DOI: 10.1073/pnas.2508912122).
• Authors highlight potential relevance for obesity and type 2 diabetes research, while noting that therapeutic applications await in vivo validation, and they report no conflicts of interest.