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Germline Genetic Variants Shape Safety and Activity of CAR‑T Therapy

Functional experiments link an inherited STXBP2 change to stronger inflammatory responses, pointing to donor selection and engineered CAR‑T strategies that require larger validation.

CAR‑T Cells Targeting GPNMB Eradicate Glioblastoma in Preclinical Models

Personalized mRNA Vaccine Halves Five‑Year Melanoma Recurrence Risk

Single CAR T Infusion Clears Residual Disease in High-Risk Smoldering Myeloma Trial

Engineered CAR-T Cells Target PD-L1 to Deliver IL-12 at Tumors, Showing Solid-Tumor Gains in Mice

AI Drives Next-Generation Melanoma Immunotherapies Toward In Vivo Testing

Modified Herpes Virus Plus Nivolumab Induces Tumor Regression in Advanced Melanoma

Cancer Cell Cholesterol Depletion Heightens Hyperthermia Treatment Efficacy