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Cell Signaling

Cyclin-Dependent Kinases Tumor Growth Chemical Signaling Cell Movement Feedback Mechanisms Tumor Microenvironment Stem Cell Differentiation STING Pathway Epidermal Growth Factor Mechanical Stress Responses

AI‑Designed Miniproteins Can Switch GPCRs On or Off, Study Reports

A Nature paper shows a pipeline that pairs computational design with a native‑cell high‑throughput screen to create preclinical GPCR drug candidates.

Lithium Chloride Rewires Alzheimer’s-Linked Pathways in Cell Study

Cells Use One-Hour ‘Low-Pass Filter’ to Decide Which Forces Trigger a Response

TIE2 Identified as Drug Target in Brain Cavernous Malformations After Mouse Study Stops New Lesions

Study Identifies FOXJ3 Mutations as a Cause of Focal Cortical Dysplasia and Drug-Resistant Epilepsy

CRISPR Scan Maps the Strength of Cancer-Driving CTNNB1 Hotspot Mutations

Lung Tumors Tap Nerve–Brain Circuit to Thwart Immunity, Mouse Study Finds

Nature Studies Identify Lipid 'Dimmer' That Tunes STING Activity

Study Pinpoints GPR25 as Switch for Tissue-Resident Memory T Cell Formation

Rapalink-1 Extends Yeast Lifespan, Revealing an Agmatinase Feedback on TORC1

Lysosome Signals Drive Histone Transfer That Extends Worm Lifespan Across Generations

ALK7 Identified as Driver of Pancreatic Cancer’s Bloodstream Entry in Preclinical Study

Lung Tumors Reprogram Bone Marrow Progenitors as NRF2 Emerges as a Target

Study Reveals Tamoxifen Triggers PI3K Pathway Linked to Uterine Cancer

Ciliary Hedgehog Signaling Redirects Fat Precursor Cell Fate in Mice

CDK12/13 Degraders Activate STING-Mediated Immunity and Enhance Checkpoint Therapy

Early Zebrafish Heartbeats Drive Self-Organizing Cardiac Trabecular Growth

DynaTag Maps Transcription Factor–DNA Interactions at Single-Cell Resolution and Uncovers Chemotherapy Resistance Dynamics

Chronic Particulate Exposure Found to Drive NRF2-Mediated Allergic Lung Inflammation

Repurposed Psoriasis Drug Restores Brain Function in Vascular Dementia Mice