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Scientists Map Bacterial Blueprint That Builds a Natural HDAC Cancer Drug

The molecular map reveals how a conserved β-hairpin docking domain links two enzyme systems and offers a validated route to engineer new depsipeptide HDAC inhibitors.

Northwestern Team Reengineers 5-FU Into DNA Nanoparticle That Strikes AML in Mouse Tests

Tumor-Induced Nerve Injury Identified as Driver of Anti–PD-1 Resistance

Blocking DKK1 Reprograms Neutrophils and Revives Immunotherapy in Bone Metastases

UCSD Validates STRESS Signature, Pursues Inhibitors to Block Pancreatic Cancer Progression

Universal mRNA Vaccine Eradicates Tumors in Mice and Advances Toward Human Trials

Benzaldehyde Disrupts Protein Interface to Thwart Pancreatic Cancer Resistance and Metastasis

High-Resolution Sequencing Reveals Millions of Mutations in Wilms Tumor and Points to Immunotherapy