Immune Response Tumor Microenvironment Immune Evasion Hypoxia Chromosomal Aberrations Intratumoral Heterogeneity Metabolism Hormonal Pathways Cell Signaling Cellular Mechanisms Targeted Therapy Dormant Tumors Microsatellite Instability Adipose Tissue Interaction Tumor Suppressor Genes Cancer Immunotherapy Tumor Growth Metabolic Reprogramming Inflammation Acidosis Tumor Aggressiveness Immune Suppression Gene Regulation Genetic Variants
The mouse-only study outlines a tunable tolerance mechanism with potential applications in autoimmunity, transplantation, and cancer.