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Drug Development

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Experimental RUNX2 Inhibitor Strengthens Bone and Reduces Weight in Menopause Mouse Model

Preclinical data point to a possible new osteoporosis approach that needs human trials to confirm safety and benefit.

TOFA Boosts Fat Burning in Mice While Preserving Muscle

Sildenafil Shows Promise in Lab Tests to Limit Cancer Spread

Human‑Safe Drug Restores Neuronal DNA Repair in Mouse Model of Alzheimer’s

Copper Compound Restores Brain Clearance Pump and Cuts Alzheimer’s Proteins in Mice

Experimental Antibody Preserves Muscle During Tirzepatide Weight Loss

ETH Zurich Pins GRK2 Aggregation as Alzheimer’s Target and Reveals 'Compound 10' That Slows Decline in Mice

Flu Drug Class Prevents Glycan Loss Linked to Cognitive Decline in People With HIV

Asthma Drug Montelukast Restores Checkpoint Response in Preclinical Cancer Models

Oral GLP-1 Weight-Loss Pills Curb Hedonic Eating by Hitting Deep-Brain Circuit in Mice

Five-Target ‘Trojan Horse’ Drug Outperforms Leading Incretins in Obese Diabetic Mice

Brazil Moves to Tighten Rules on GLP‑1 Weight‑Loss Pens as Demand Surges

Mouse Study Maps Serotonin Circuit That Triggers Tinnitus-Like Signals

TIE2 Identified as Drug Target in Brain Cavernous Malformations After Mouse Study Stops New Lesions

Arvinas’ ARV-102 Hits >50% LRRK2 Degradation in Phase 1 Parkinson’s Trial

Sildenafil Shows Early Benefit in Leigh Syndrome as Europe-Wide Trial Is Planned

Xenon to Present Topline X-TOLE2 Phase 3 Results in Focal Onset Seizures at 8 A.M. ET Today

Anti-Seizure Drug Levetiracetam Blocks Early Alzheimer’s Protein Production, Study Finds

Alzheimer’s Study Finds Memory “Replay” Persists but Loses Structure

Restoring NAD+ Reverses Alzheimer’s Signs in Mice, Study Finds