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Clinical Trials

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Study Finds TGF-β Builds Dual Immune Barrier in Metastatic Colorectal Cancer

The Nature Genetics paper highlights targetable signals to boost checkpoint therapy in liver metastases.

Triple Therapy Counters Endocrine Resistance in ER+ Breast Cancer in Preclinical Study

Study Ties CGRP–RAMP1 Signaling to GI Tumor Growth, Pointing to Repurposed Migraine Therapies

FDA Reapproves GSK’s Blenrep for Multiple Myeloma in Narrow Combination Use

First Human Trial Finds Enteral Ventilation Safe in Healthy Volunteers

UC San Diego AI Identifies PRKAB1 Target to Reprogram Colon Cancer Stem Cells

Endoxifen Add-On Restores Tamoxifen Levels in Poor Metabolizers, Phase 1/2 Trial Finds

FDA Clears UCLA’s ENPP1-Blocking Antibody AD-NP1 for First-in-Human Trial

Cannabis Extract VER-01 Eases Chronic Low Back Pain in Phase 3 Trial

UC Researchers Target Hsp70 to Counter Pancreatic Cancer Immunosuppression With Preclinical Nanovesicle Therapy

Regeneron’s Garetosmab Slashes New Bone Lesions in FOP Phase 3, U.S. Filing Planned This Year

Azelastine Nasal Spray Cut COVID-19 Infections in Phase 2 Trial

Metformin Use Tied to Lower Copper and Iron, Higher Zinc in Human Study

STAT3 Decoy Shows Early Promise in First Cat Cancer Trial, Pointing Toward Human Studies

MD Anderson Debuts PreCiSE, a Genome-Wide CRISPR Platform for Primary NK Cells

Tumor-Induced Nerve Injury Identified as Driver of Anti–PD-1 Resistance

GSDMD Inhibitor YM81 Lowers Liver Injury Markers in Acetaminophen-Overdose Mice

Blocking DKK1 Reprograms Neutrophils and Revives Immunotherapy in Bone Metastases

Astrocyte-Derived Peptide Achieves Nausea-Free Weight Loss in Animal Models

UC San Diego Launches Clinical Trial of Sequenced Radiotherapy and Immunotherapy for Head and Neck Cancer