Therapeutics

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UCSF, UCLA Pinpoint CUL5 Complex That Clears Toxic Tau in Human Neurons

Stronger activity in a ubiquitin‑ligase complex correlated with neuron survival in Alzheimer’s brain tissue.

Cancer Protein Cystatin‑C Triggers Amyloid Clearance in Alzheimer’s Mouse Models

Gut Macrophages Propel Parkinson’s-Like Spread to the Brain in UCL Mouse Study

Northwestern Team Demonstrates Wireless Micro‑LED Implant That Encodes Information in Mouse Brains

Single Psilocybin Dose Rewires Brain-Wide Circuits in Mice, Cell Study Finds

Study Pinpoints GPR25 as Switch for Tissue-Resident Memory T Cell Formation

UMC Utrecht Reports First FcγRI-Blocking Antibodies With Preclinical Efficacy

Inflammatory Cells Rewire Bone Marrow Niche Early in CHIP and MDS, Study Finds

New Study Links Motor Neuron Size to ALS Vulnerability Through Proteostasis Burden

Long-Read Sequencing and 'LongTrack' Map Donor Bacteria After Fecal Transplants

Study Ties Obesity to Alzheimer’s Plaque via Fat-Derived Vesicles

PET Study Finds Early Brain Inflammation in Down Syndrome Linked to Amyloid

Study Identifies Stress-Activated Ubiquitin Precursor That Enhances Proteostasis and Longevity

KAIST Links Enlarged Cancer Nuclei to Replication Stress That Slows Metastasis in Mice

Engineered RyR1 Mouse Shows CICR Is Dispensable for Contraction and Central to Hyperthermia Risk

HIV-1 Tat Shown to Undermine Cell Defenses, Boosting TB in Preclinical Study

Study Identifies CD82–Cholesterol Switch That Drives Vascular Leakage

Human iPSC Stem Cell Grafts One Week After Stroke Restore Function in Mice

Custom CRISPR Base Editor Corrects ACTA2 Mutation in Mice, Extending Survival Fourfold

Lung Tumors Reprogram Bone Marrow Progenitors as NRF2 Emerges as a Target