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Northwestern Team Demonstrates Wireless Micro‑LED Implant That Encodes Information in Mouse Brains

Published in Nature Neuroscience, the soft transcranial device delivers programmable patterns through the skull to drive behavior in genetically sensitized mice.

Overview

  • The implant sits beneath the scalp on the skull and uses red light to activate cortical neurons across multiple regions through bone.
  • An array of up to 64 independently controlled micro‑LEDs enables complex spatiotemporal stimulation that mirrors distributed sensory activity.
  • In behavioral tests, mice learned to identify a specific light pattern among many and used it to choose the correct reward port, evidencing artificial perception.
  • The system is battery‑free, wirelessly powered, roughly the size of a postage stamp, and can be programmed in real time without altering natural behavior.
  • Researchers plan to expand array density and wavelengths and probe how many distinct codes the brain can learn, with therapeutic uses discussed as future possibilities.