Oxford is the 14th most populous city in Mississippi, United States, and the county seat of Lafayette County, 75 miles southeast of Memphis. A college town, Oxford surrounds the University of Mississippi or "Ole Miss". Founded in 1837, the city is named for Oxford, England.
Purchasing the land from a Chickasaw, pioneers founded Oxford in 1837. In 1841, the Mississippi State Legislature selected it as the site of the state's first university, Ole Miss. From Wikipedia