Esketamine, sold under the brand names Spravato and Ketanest among others, is the S enantiomer of ketamine. It is a dissociative hallucinogen drug used as a general anesthetic and as an antidepressant for treatment of depression. From Wikipedia
Starting May 1, Spravato becomes the first new government-funded antidepressant in 30 years, offering rapid relief but with ongoing cost and access challenges.