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Tumor Biology

Tumor Microenvironment Pancreatic Ductal Adenocarcinoma PRAME Expression Immune Response Chromosomal Instability Circulating Tumor Cells NECTIN4 Expression RNA-Binding Proteins Targeted Cancer Therapies Tumor Immunology Glycan Targeting SMARCA4-Deficient Tumors

Study Identifies TSP‑1–CD47 Signal That Drives T‑Cell Exhaustion in Cancer

The peer‑reviewed work points to a targetable immune‑suppressive cue with preclinical evidence of restored T‑cell function.

Engineered CAR-T Cells Target PD-L1 to Deliver IL-12 at Tumors, Showing Solid-Tumor Gains in Mice

Preclinical Candidate AVJ16 Blocks IGF2BP1 to Halt Lung Tumor Growth in Models

Glycan-Targeting ‘GlyTR’ Therapy Kills Diverse Cancers in Preclinical Tests

Genomic Test Predicts Chemotherapy Resistance in Cancer Patients