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Solid Tumors

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New CAR-T Designs Deliver Low-Dose Remissions and Expose a Senescence Risk

Early data suggest stronger, safer products that still need larger trials.

First-in-Human SynKIR-110 Shows Safe Profile and Early Activity in Solid Tumors

CD70-Targeted HIT Cells Eradicate Solid Tumors in Mice

Pliant’s PLN-101095 With Keytruda Shows Early Responses in PD-1–Refractory Solid Tumors

Engineered CAR-T Cells Target PD-L1 to Deliver IL-12 at Tumors, Showing Solid-Tumor Gains in Mice

Next-Generation CAR-T Therapies Deliver Remission in T-Cell Cancers and Extend Survival in Gastric and Brain Tumors