Health ❯ Genetics ❯ Genetic Disorders

Down Syndrome

Trisomy 21 Congenital Heart Defects HMGN1 Gene Amyloid Precursor Protein

Excess HMGN1 Identified as Driver of Down Syndrome Heart Defects

Researchers trace Down syndrome heart defects to excess HMGN1 using mosaic cell models, CRISPRa screens, with rescue confirmed in mice.

PET Study Finds Early Brain Inflammation in Down Syndrome Linked to Amyloid