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DNA Repair

Double-Strand Breaks Naked Mole Rat DNA Polymerase β Polβ Enzyme DNA-Protein Crosslinks CIRBP Telomeres SPRTN Enzyme DNA Damage Cancer Research Cellular Mechanisms Microsatellite Instability Mutation Analysis Oxidative Stress Memory Encoding Radiation Resistance DNA Repair Genes ZNF280A Polβ Human REPAIRome Repair Proteins Synthetic Lethality Aging Research NF-κB Signaling Pathway Aging Microhomology-Mediated End Joining

Unrepaired DNA‑Protein Crosslinks Drive Inflammation‑Linked Premature Aging, Study Finds

The work identifies cGAS‑STING as a therapeutic target for disorders caused by defective DNA‑protein crosslink repair.

Mouse Study Ties Gray Hair to a Stem Cell Safety Switch Linked to Melanoma Risk

Four Naked Mole-Rat cGAS Mutations Boost DNA Repair, Extend Healthspan in Model Organisms

CNIO Releases 'Human REPAIRome' Mapping 20,000 DNA Repair Scars

Nature Study Reveals How RAP1 Blocks DNA-PK to Safeguard Telomeres

Polβ Repair Enzyme Found to Protect Developing Neurons From CpG-Linked DNA Mutations