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Solid Tumors

Melanoma Advanced Cancers Gastric Cancer Prostate Cancer Ovarian Cancer

Engineered CAR-T Cells Target PD-L1 to Deliver IL-12 at Tumors, Showing Solid-Tumor Gains in Mice

The strategy tethers IL-12 to a PD-L1 blocker to concentrate immune activation at the tumor with minimal systemic toxicity.

Next-Generation CAR-T Therapies Deliver Remission in T-Cell Cancers and Extend Survival in Gastric and Brain Tumors