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2h ago

Zuckerbergs Make Biohub Their Main Philanthropy, Putting AI–Biology at the Center

The move concentrates long-horizon funding on virtual biology powered by a 10,000‑GPU buildout by 2028.

Priscilla Chan, co-founder and co-CEO of the Chan Zuckerberg Initiative (CZI), speaks during an event at the Biohub Imaging Institute in Redwood City, Calif., Wednesday, Nov. 5, 2025. (AP Photo/Jeff Chiu)
Dr. David Baker, Nobel laureate in chemistry, speaks during an event at the Biohub Imaging Institute in Redwood City, Calif., Wednesday, Nov. 5, 2025. (AP Photo/Jeff Chiu)
Image
Meta CEO Mark Zuckerberg, right, speaks next to his wife, Priscilla Chan, co-founder and co-CEO of the Chan Zuckerberg Initiative (CZI), during an event at the Biohub Imaging Institute in Redwood City, Calif., Wednesday, Nov. 5, 2025. (AP Photo/Jeff Chiu)

Overview

  • Biohub unveiled a flagship Virtual Immune System and a unified AI model of the cell as part of four stated grand challenges.
  • EvolutionaryScale was acquired, with co-founder Alex Rives joining as head of science to lead integrated AI, data, and experimental biology.
  • Compute capacity will expand tenfold to 10,000 GPUs by 2028 to support training and large-scale biological modeling.
  • New open models were released: VariantFormer for translating genetic variants to tissue-specific gene activity, CryoLens for cryo‑ET structural analysis, and scLDM for generating realistic single‑cell data.
  • CZI is reallocating resources toward Biohub, with reporting of roughly $1 billion in annual operations and the winding down of DEI grants and The Primary School.