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11h ago

Year-Long, Very-High-Fat Keto Diet Triggers Metabolic Harm in Mice

The University of Utah team found the glucose defect reversed after the diet ended, with human implications still uncertain.

Assortment of healthy ketogenic low carb food ingredients including green vegetables, meat, salmon, cheese and eggs.
Keto diet is a combination of protein, fibre and fats.

Overview

  • Mice fed an approximately 90% fat ketogenic regimen for about a year developed severe glucose intolerance, high blood lipids and impaired insulin secretion.
  • Male animals also showed fatty liver and signs of liver dysfunction, according to results published September 19 in Science Advances.
  • Despite early weight loss on the ketogenic plan, the study reports no lasting reduction in body weight over the long term.
  • Ending the diet restored the mice’s ability to handle glucose, suggesting at least that effect was reversible in this model.
  • Researchers and outside clinicians caution that these findings in mice may not translate directly to people and advise medical supervision for prolonged ketogenic dieting.