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World’s First Human Bladder Transplant Successfully Performed in Los Angeles

USC and UCLA surgeons achieve a medical milestone with a combined kidney and bladder transplant, restoring renal and urinary function in a clinical trial patient.

Surgeons perform the first ever human bladder transplant on May 4, 2025 at UCLA Medical Center. (Nick Carranza/UCLA Health)
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Overview

  • The groundbreaking procedure was completed on May 4, 2025, at Ronald Reagan UCLA Medical Center, marking the first successful human bladder transplant.
  • Led by Dr. Inderbir Gill of USC Urology and Dr. Nima Nassiri of UCLA, the surgery involved an eight-hour operation to transplant both a kidney and a bladder.
  • The patient, who had been dialysis-dependent for seven years, immediately produced urine post-surgery and no longer requires dialysis.
  • The transplant is part of a UCLA-led clinical trial aimed at evaluating the safety, feasibility, and long-term outcomes of bladder transplantation.
  • Years of preclinical research, including robotic-assisted procedures and collaborations with OneLegacy, were critical to refining the technique and ensuring its success.