Overview

• Global estimates point to about 500 million undiagnosed cases and up to 37 million fragility fractures each year, or roughly 70 every minute, according to the International Osteoporosis Foundation.
• One in three women and one in five men over 50 are at risk of osteoporotic fractures, with updated guidance underscoring effective diagnosis and treatment in men.
• Clinicians flag wrist or vertebral “sentinel” fractures as an alarm, noting a first osteoporotic break doubles the likelihood of another without targeted therapy.
• Bone mineral density testing remains the diagnostic standard, and fracture-liaison services are scaling — including 37 centers in Mexico — to coordinate secondary prevention.
• Treatment options now include RANKL-targeting monoclonal antibodies and a sclerostin inhibitor, with studies reporting fracture reductions up to 68% overall and 73% for new spinal fractures within 12 months.