Overview

• The 49ers ruled out quarterback Brock Purdy and wide receivers Ricky Pearsall (knee) and Jauan Jennings (ribs/ankle) for Thursday night, with Mac Jones confirmed to start.
• George Kittle remains on injured reserve and past losses include Nick Bosa, further taxing San Francisco’s depth on a short week.
• Jones enters for his third start after two earlier wins, and reporting indicates Kyle Shanahan is expected to lean on Christian McCaffrey and a high-percentage passing plan.
• Sportsbooks shifted the spread sharply toward Los Angeles, moving the Rams to roughly a touchdown or more favorite after the 49ers’ final injury report.
• The Rams list right tackle Rob Havenstein (ankle) and tight end Tyler Higbee (hip) as doubtful, and Puka Nacua is expected to play; kickoff is 8:15 p.m. ET on Amazon Prime Video with local simulcasts.