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Whole Mouse Cortex Simulated at Near-Cellular Detail on Japan's Fugaku

Powered by Japan's Fugaku supercomputer, the model offers a new in silico testbed for brain disorders.

Overview

  • The team modeled nearly 10 million neurons, about 26 billion synapses, and 86 interconnected regions to capture biophysical activity neuron by neuron.
  • Researchers combined Allen Institute datasets and the Brain Modeling ToolKit with the Neulite simulator to translate real cell properties into a working digital cortex.
  • Fugaku, jointly developed by RIKEN and Fujitsu, delivered the compute with more than 400 quadrillion operations per second across 158,976 nodes.
  • Project leads say the platform will let scientists probe disease mechanisms such as Alzheimer's and epilepsy and test hypotheses in a virtual environment.
  • The work is under review with publication coordinated for the SC25 supercomputing conference, and investigators describe it as a first step toward whole-brain and eventually human-scale models.