Overview
- President Trump urged pregnant women to avoid acetaminophen, triggering immediate rebuttals from health authorities.
- WHO and the European Medicines Agency reaffirmed that current evidence does not establish causation and maintained guidance to use the lowest effective dose when clinically necessary.
- A 2024 JAMA sibling-comparison study of 185,909 Swedish births found no increased risk of autism, ADHD or intellectual disability with prenatal exposure.
- An Environmental Health review published in August 2025 assessed 46 studies and reported mixed results with moderate, biased evidence that does not prove causality.
- Clinicians warn that discouraging indicated treatment risks undertreating fever and pain in pregnancy, and they note folinic acid (leucovorin) is for specific metabolic deficits rather than preventive use.