Overview

• President Trump and HHS said acetaminophen use during pregnancy can be associated with increased autism risk and urged pregnant patients to limit use unless medically necessary.
• Trump said the FDA will notify clinicians and start a Tylenol safety label change; agency communications reported by outlets note a causal relationship has not been established.
• The administration promoted leucovorin as a potential therapy for some autism symptoms, with Trump saying the FDA is updating labeling, and NIH announced $50 million for an Autism Data Science Initiative.
• Kenvue and major medical organizations, including ACOG, rejected claims of causation and cautioned that alarming messages could deter treatment of fever and pain in pregnancy.
• Recent reviews report associations based on observational data, while a large 2024 Swedish sibling study found no causal link, underscoring ongoing scientific uncertainty as federal research proceeds.