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Weight-Loss Pills Could Trim Airline Fuel Costs, Jefferies Says

A new Jefferies model ties rising GLP-1 pill use to lighter planes, projecting measurable fuel savings for major U.S. carriers.

Overview

  • Jefferies estimates slimmer passengers using GLP-1 drugs could save the four largest U.S. airlines up to $580 million in fuel costs this year.
  • The firm models a 10% drop in average passenger weight translating to roughly 2% lower aircraft weight, up to 1.5% less fuel burned, and as much as a 4% EPS uplift.
  • Illustrative EPS impacts include about 2.8% for Delta, 3.5% for United, 4.2% for Southwest, and up to 11.7% for American.
  • Jefferies projects the big four will burn about 16 billion gallons of fuel in 2026, with a combined bill near $39 billion, roughly 19% of operating expenses.
  • Novo Nordisk’s GLP-1 pill is already reaching patients and a similar Eli Lilly pill is expected within months, while surveys report about one in eight U.S. adults using GLP-1s and Gallup pegs adult obesity at 37%.