Overview

• WEHI scientists have developed a strategy to enhance stem cell-like memory CD8+ T cells using mRNA vaccines and transient type I interferon inhibition.
• The study, published in the Journal of Experimental Medicine, demonstrated durable immune protection in preclinical mouse models.
• This approach could reduce dependence on frequent booster shots by promoting long-lasting cellular immunity.
• The findings also highlight potential applications in cancer immunotherapy by boosting T cells capable of targeting tumors.
• The next step involves translating this breakthrough to human clinical trials to assess its broader therapeutic potential.