Overview
- The FDA cleared the oral semaglutide in late December, and pharmacies began stocking it on January 5 with availability reported at more than 70,000 locations and via telehealth providers.
- Clinical data and physicians indicate the tablet delivers weight loss similar to the injectable version when paired with diet and exercise.
- Patients switching from injections are advised to wait one week after the last shot, take the pill first thing on an empty stomach with up to 4 ounces of water, and wait at least 30 minutes before food or other medications.
- Uninsured cash prices are reported around $149 to $299 per month, and doctors note the pill is cheaper to produce than pen injections and does not require refrigeration.
- Common side effects include nausea and diarrhea with rare risks such as thyroid tumors and pancreatitis, and clinicians warn against non‑FDA compounded versions sold online.