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Week 6 NFL Shake-Up: 49ers Lose Fred Warner for the Season as Jets Fall to 0-6 and Breakouts Reorder the Race

A major 49ers injury alongside dramatic swings in form reset early‑season trajectories.

Overview

  • Kyle Shanahan confirmed Fred Warner suffered a dislocated and broken ankle and will have season‑ending surgery, dealing San Francisco a significant defensive blow.
  • New York’s trip to London produced a nadir: Justin Fields completed 9 of 17 for 45 yards, took nine sacks, and the Jets finished with minus‑10 net passing yards to drop to 0‑6.
  • Baker Mayfield strengthened an early MVP case by going 17 of 23 for 256 yards and two touchdowns as Tampa Bay improved to 5‑1 despite key receiver injuries.
  • Carolina’s Rico Dowdle became the first Panthers back with consecutive 180‑plus rushing games, posting 183 yards on 30 carries and adding 56 receiving yards and a touchdown to move Carolina to 3‑0 at home.
  • Pittsburgh climbed to 4‑1 with a win over Cleveland while the rest of the AFC North lost, giving the Steelers early control of the division race.