Overview

• SportsLine’s simulation model lists Dallas -3 at Carolina as a top play, projecting the Cowboys to cover with CeeDee Lamb ruled out again after the offense produced 77 points over the last two games.
• Tampa Bay is also flagged to cover at home against San Francisco, with the 49ers without Brock Purdy and backup Mac Jones listed as questionable as the Buccaneers lean on a top-10 offense and Baker Mayfield’s 10:1 TD-to-INT start.
• Sportsbooks posted several lopsided Week 6 lines, including Rams -7 vs. a Ravens team missing Lamar Jackson, Colts -8.5 with Kyler Murray expected out for Arizona, and Packers -14.5 as Joe Flacco debuts for Cincinnati.
• CBS Sports reports the SportsLine model simulates each game 10,000 times and claims more than $7,000 in gains for $100 bettors on top-rated picks with a 41-21 run since 2024.
• Independent picks from Bleeding Green Nation include Cowboys -3 and Buccaneers -3.5 among their selections, along with plays such as Steelers -6.5 and Bengals +14.5.