Overview

• Books reported winning results after major favorites fell, with South Point and The SuperBook citing the Rams, Cardinals and Bills losses as key outcomes and BetMGM showing roughly 90% of moneyline tickets on Buffalo before its defeat.
• Week 5 produced six double-digit comeback wins, tied for the most in a single week in league history, underscoring unusual volatility for bettors.
• Futures shifted after Philadelphia’s first loss, with the Eagles no longer atop some NFC boards and Detroit installed as DraftKings’ new favorite at +340.
• Week 6 previews lean into underdogs, as FOX Sports’ Geoff Schwartz recommends Lions +2.5 at Kansas City and CBS Sports places several favorites on upset watch.
• Short-week context features both models and injuries: ESPN Analytics gives Philadelphia a 74.8% chance over New York as Saquon Barkley was upgraded to limited, a development Giants DT Dexter Lawrence said they can’t allow to become a breakout.