Week 5 NFL Betting Guide: Parlays, ATS Picks and Key Odds for Broncos–Eagles and Chiefs–Jaguars

Updated odds alongside key availability updates shape Week 5 betting calls, notably Jayden Daniels' expected return.

Overview

SportsLine’s Jeff Hochman released two parlays, backing money-line favorites including the Chiefs over the Jaguars and an underdog ticket featuring the Broncos over the Eagles, the Buccaneers over the Seahawks and the Titans over the Cardinals.
Newsweek’s early against-the-spread card from Tyler Everett covers all 14 games, with picks such as Eagles -3.5 vs. the Broncos, Buccaneers +3.5 at the Seahawks, Commanders +2.5 at the Chargers and Chiefs -3.5 at the Jaguars.
Yahoo Sports lists current BetMGM prices showing Philadelphia favored over Denver (Broncos +170/Eagles -210) and Kansas City favored at Jacksonville (Chiefs -175/Jaguars +145), with the Chargers -2.5 against Washington.
Trend analysis highlights Philadelphia’s strong overall cover rate but recent home ATS slippage, plus Kansas City’s sustained success against Jacksonville, including a multi-game win and cover streak in the Mahomes era.
CBS Sports notes money-line favorites have delivered roughly two-thirds win rates in recent seasons, with a 68.7% hit rate through four weeks of 2025, as market notes factor in Daniels’ expected return for Washington and the Chargers’ tackle injuries.