Overview

• Sportsbooks post updated lines for a smaller slate, including Colts -7 vs. Raiders, Eagles -3.5 vs. Broncos, Seahawks -3 vs. Buccaneers, Bills -8.5 vs. Patriots on Sunday night and Chiefs -3.5 vs. Jaguars on Monday night.
• Miami will proceed without Tyreek Hill for the season due to a knee injury, and Baltimore is expected to be without Lamar Jackson in Week 5 with a hamstring issue, shifting market expectations.
• SportsLine’s simulation model backs the Saints (-1.5) to cover against the Giants and the Cardinals (-7.5) over the Titans, with additional graded picks across every matchup.
• DFS guidance from SportsLine expert Mike McClure spotlights Breece Hall and Jaxon Smith-Njigba as core Sunday targets on DraftKings and FanDuel.
• USA TODAY’s Week 5 D/ST rankings highlight Vikings, Lions and Cardinals as top options, with Vikings-Browns kicking off in London at 9:30 a.m. ET.