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Week 5: Dolphins at Panthers, With Miami Slightly Favored in First Game Without Tyreek Hill

Oddsmakers make Miami a 1.5-point favorite following a run-focused pivot that elevates De'Von Achane.

Carolina Panthers v New England Patriots
Dolphins running back De’Von Achane and receiver Jaylen Waddle celebrate Waddle’s touchdown catch against New England on Sunday, Sept. 14, 2025, at Hard Rock Stadium in Miami Gardens. (Joe Cavaretta/South Florida Sun Sentinel)
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Miami Dolphins head coach Mike McDaniel speaks before practice at the Baptist Health Training Complex in Miami Gardens on Thursday, Sept. 25, 2025. (Carline Jean/South Florida Sun Sentinel)

Overview

  • Kickoff is Sunday, Oct. 5 at 1 p.m. ET on FOX at Bank of America Stadium in Charlotte.
  • Both teams are 1-3 entering Week 5, with betting lines at roughly Dolphins -1.5 and most expert picks siding with Miami.
  • Miami starts its post-Tyreek plan after his season-ending knee injury, emphasizing the run following De'Von Achane’s 20 carries for 99 yards in the win over the Jets.
  • Carolina’s form has been erratic, swinging from a 30-0 home shutout of Atlanta to a 42-13 loss at New England, with Bryce Young’s output uneven.
  • Analysts highlight a matchup edge for Miami’s rushing attack against a Panthers run defense ranked near the bottom, with recent Dolphins takeaways offering potential field-position boosts.