Overview

• Jacksonville (2-1) travels to Levi's Stadium to face undefeated San Francisco (3-0) on Sunday, Sept. 28.
• Several USA TODAY panelists report Nick Bosa is out for the season and note uncertainty at quarterback, with Brock Purdy described as a possible starter and Mac Jones as banged-up.
• Jacksonville enters with a league-best pressure rate allowed of 9.2% and a +5 turnover differential, tied for first.
• San Francisco’s defense allows 16.3 points per game (third), but its pass rush ranks near the bottom by pressure rate and its turnover margin sits at -1.
• The 49ers lead the all-time series 5-2, including a 34-3 win in 2023, yet current betting outlooks show analysts divided between Jaguars +3.5 and 49ers -3.5.