Overview

• Major sportsbooks released lines for all 16 games, with Arizona around -1.5 and a total near 43.5 for Thursday night.
• Thursday’s matchup streams exclusively on Prime Video at 8:15 p.m. ET, and Sunday includes Vikings–Steelers in Dublin on NFL Network.
• Reports indicate James Conner’s ankle injury ends his season, pushing Trey Benson into a larger role for the Cardinals.
• Several previews pick Seattle despite the market leaning to Arizona, while ESPN’s model gives the Cardinals a slight win probability edge.
• Opening numbers reflect modest shifts from look-ahead lines, and Week 4 concludes with Jets–Dolphins and Bengals–Broncos on Monday night.