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Week 15 NFL: AI Picks, Odds and Injuries Frame a Nearly All-Meaningful Slate

Only Commanders–Giants lacks playoff impact, with predictions arriving as availability questions linger.

Overview

  • Fifteen of 16 games carry playoff implications, with the lone exception identified as Commanders at Giants.
  • SportsLine AI posted picks for every matchup and rates the Cowboys (-5.5) as an A+ spread play, projecting an average 30–20 win over the Vikings.
  • CBS Sports’ 10,000-simulation model backs the Saints to cover at Carolina and the Giants to cover against Washington based on recent performance and matchup metrics.
  • Books list Buffalo -1.5 at New England and the Rams -6 over Detroit, with several double-digit spreads including the Eagles, 49ers, Jaguars and Seahawks.
  • Injury variables include Jayden Daniels’ elbow status uncertain for Washington, the Colts listing rookie Riley Leonard without committing to a starter, and the Steelers expected to be without T.J. Watt on Monday.