Overview
- Week 12 features 14 games from Thursday’s Bills–Texans opener to Monday night’s Panthers–49ers finale.
- The 49ers are around a 7-point favorite over the Panthers at BetMGM (San Francisco -300, Carolina +240, total 47.5), and ESPN Analytics gives San Francisco about a 72% win chance.
- SportsLine’s 10,000-simulation model has locked in five Week 12 best bets and promotes a parlay that would pay roughly 25-to-1.
- SportsLine AI and CBS projections grade Seattle at Tennessee as an A+ spread play, projecting about a 30–14 Seahawks win with simulations showing strong win and solid cover probabilities.
- Marquee matchups include Colts–Chiefs and Vikings–Packers, with market lines favoring Kansas City (-3.5) and Green Bay (-6.5) as some power ratings elevate Indianapolis to the league’s top tier.