Overview
- Week 12 features 14 games from Thursday to Monday, headlined by Bills at Texans on Prime Video, Buccaneers at Rams on NBC, and Panthers at 49ers on ESPN.
- BetMGM lists San Francisco as a 7-point favorite over Carolina on Monday night, with roughly a -300 moneyline and a 47.5-point total.
- ESPN Analytics’ Matchup Predictor puts the 49ers’ win probability at 72.4% against the Panthers.
- SportsLine is touting a roughly 25-1 five-leg parlay, and its self-learning AI grades Seahawks -13/-13.5 at Titans as an A+ spread pick after extensive simulations.
- Injury and roster notes shaping outlooks include the Falcons placing Michael Penix Jr. on IR with Kirk Cousins next up, a wrist injury for Pittsburgh’s Aaron Rodgers, Cleveland monitoring Shedeur Sanders for a potential first start, and the Jets turning to Tyrod Taylor at quarterback.