Overview
- The 6-4 49ers visit the 3-6 Cardinals at State Farm Stadium on Sunday, Nov. 16, with kickoff at 4:05 p.m. ET on FOX.
- Opening betting lines list San Francisco at -1.5 with a -122 moneyline and an over/under of 47.5.
- USA TODAY’s panel largely picked the 49ers against the spread, projecting a clearer result than the teams’ close meeting earlier this season.
- Panelists cite San Francisco’s resilience through injuries and skepticism about Arizona’s offense, with one noting the 49ers remain favored on the road despite being banged up.
- Niners Wire reports Kyler Murray is on IR with a foot injury and Brissett is 1-3 as the starter, while the broadcast will be regional rather than national.