Overview
- Mac Jones is set for a sixth straight start for the 49ers, with Brock Purdy limited, questionable, and taking scout‑team reps to mimic Matthew Stafford.
- The 49ers enter without key defensive pieces including Fred Warner and Nick Bosa, and their struggling pass rush faces Stafford, who leads the NFL in touchdown passes and threw for 389 yards in the first meeting.
- Experts and betting lines largely lean toward Los Angeles, with several national panels picking the Rams and books listing them as road favorites for the NFC West rematch San Francisco won in overtime in Week 5.
- Christian McCaffrey continues to drive the 49ers’ offense, leading the league in touches and total yards from scrimmage while nearing another dual 600‑yard rushing/receiving season.
- On Monday night, injury-hit Green Bay remains a consensus betting favorite against Philadelphia as the Eagles integrate deadline additions Jaelan Phillips, Jaire Alexander and Michael Carter II, and metrics point to a Packers opportunity against Philadelphia’s vulnerable run defense.