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Water-Based Lignin Extract Demonstrates Potent Antiviral and Antibacterial Activity

Mechanistic imaging uncovers distinct modes of viral inactivation with bacterial membrane damage for sustainable antimicrobial applications.

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Overview

  • Researchers at the University of Jyväskylä isolated high-purity lignin from birch chips, wheat straw and oat husks using a simple water-based extraction that preserves phenolic content.
  • In vitro assays in BSL-2 and BSL-3 laboratories showed stronger antiviral efficacy against SARS-CoV-2 than against the seasonal human coronavirus HCoV-OC43.
  • Transmission electron and confocal microscopy revealed lignin-induced aggregation of enterovirus particles and structural disruption of coronavirus envelopes.
  • Lignin inhibited Staphylococcus aureus and Escherichia coli by damaging bacterial cell membranes and disrupting internal structures.
  • Conducted with Spinnova Oy and CH Bioforce, the peer-reviewed study positions lignin as a sustainable antimicrobial for coatings, packaging and disinfectants pending scale-up and regulatory approval.