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Warwick Diamond Sensor Detects Cancer Tracers With 10 mm Handheld Probe

Lab tests show the device senses iron‑oxide tracers at doses far below current practice without using radiation.

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Overview

  • Published in Physical Review Applied, the University of Warwick team reports a compact nitrogen‑vacancy diamond magnetometer using a 0.5 mm³ diamond and an attached permanent magnet.
  • The probe detects about one hundredth of a typical clinical dose of magnetic tracer fluid, with thresholds around 2.8 mg/ml and 0.56 mg iron, and can register signals up to 14.6 mm at high concentrations.
  • Designed for sentinel lymph node localization, the sensor tracks iron‑oxide nanoparticles such as MagTrace that migrate with potential metastases from tumors.
  • Clinician collaborators at UHCW highlight current use of magnetic localization in practice, while the diamond device remains preclinical and requires engineering refinements, clinical trials, and regulatory evaluation.
  • Reported limitations include reduced range at lower concentrations and signal variability from nanoparticle distribution, with proposed upgrades such as a smaller head and stronger or multiple magnets and possible applications beyond breast cancer.