Overview
- The study, conducted by Lund University and Malmö University Hospital, followed 1,792 participants aged 45–73 over a median of 12.6 years, recording 132 heart failure events.
- A one standard deviation increase in waist-to-height ratio (WtHR) was associated with a 34% higher risk of heart failure, independent of confounders such as age, sex, and diabetes status.
- Individuals in the highest WtHR quartile faced nearly three times the risk of heart failure compared to those in lower quartiles, with a median WtHR of 0.65 exceeding the 0.5 cardiometabolic risk threshold.
- Researchers emphasized WtHR’s superiority over BMI, highlighting its ability to directly measure central adiposity, a key driver of systemic inflammation and heart failure pathogenesis.
- Future research aims to validate WtHR’s predictive value for other cardiometabolic disorders in larger, more diverse cohorts, potentially paving the way for its integration into routine clinical assessments.