Overview

• Vitamin D increases the presence of Bacteroides fragilis in mice, improving their resistance to cancer.
• Research indicates potential human benefits, with lower vitamin D levels associated with higher cancer risk.
• Mice on vitamin D-rich diets showed better responses to immunotherapy treatments.
• The effect of vitamin D on cancer immunity may be mediated by its action on intestinal epithelial cells.
• Further studies are required to explore the mechanisms by which vitamin D influences the gut microbiome and cancer immunity.